[Gambas-user] Reduced activity

[Jussi Lahtinen]

OK, it seems there are multiple explanations.
India (like some other poor countries) do not have infrastructure for all
the autopsies, corona testing, etc. So, the numbers are heavily
under-reported. See:
https://www.medrxiv.org/content/10.1101/2021.07.20.21260872v1  (<-- still
in preprint!)

Also their age structure is very different. Example in Finland a bit over
20% of people are 65 years old or older (this is a little bit higher than
in Europe generally).
In India only a bit under 7% are 65 or older!


Jussi


On Sat, Dec 4, 2021 at 1:49 AM Jussi Lahtinen <jussi.lahtinen at gmail.com>
wrote:

> I will look later, if there is an explanation for the Indian numbers.
> However, ivermectin and doxycycline do not explain it.
>
> In vitro studies have shown that ivermectin works in principle, but in
> practice the needed concentration is too neurotoxic. It is mostly a cheap
> and desperate attempt, when nothing else is available. Thus it is not used
> in western countries.
>
> Here is quote from the review: "The blood levels of ivermectin at safe
> therapeutic doses are in the 20–80 ng/ml range, while the activity against
> SARS-CoV2 in cell culture is in the microgram range."
>
> So, *you need a thousand times more ivermectin, than the safe limit.*
> Full review here: https://www.nature.com/articles/s41429-020-0336-z]
>
> There are some clinical trials still going on with ivermectin, but so far
> the results are conflicting. Either "no help and just side-effects" or
> "some very small help".
> Also there are tons of studies with severe quality issues (again, more in
> the Cochrane review).
>
> I haven't look into the data, but some have suggested that ivermectin
> generally works better in countries where the patients carry parasites. At
> least that is logical, ivermectin is antiparasitic and parasites make us
> weak.
> Also it should be noted that there are already over thousand deaths due
> self-medication with it. It should not be used until we know better, but it
> doesn't look good.
> For more details I recommend Cochrane review:
> https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full
>
> Also, note that ivermectin is in use in many countries without much
> success.
>
> Doxycycline is an antibiotic, which blocks protein synthesis of a broad
> spectrum of bacteria. So, in case of COVID induced co-infection it is used
> in western countries.
> It has also by some unknown mechanism some potential activity for some
> viruses. But at least a trial done in the UK, showed it doesn't work
> against COVID.
>
> https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00310-6/fulltext
> So, it seems the case is very similar to the ivermectin.
>
> We do not eat them for a reason and it is not a conspiracy.
>
>
> Jussi
>
>
>
>
>
> On Sat, Dec 4, 2021 at 12:44 AM T Lee Davidson <t.lee.davidson at gmail.com>
> wrote:
>
>> On 12/3/21 1:50 PM, Christof Thalhofer wrote:
>> > And is India (336) so good because there exists a natural immunity? Or
>> are their numbers simply not right?
>>
>> Perhaps it is because the Indian government provided their people with
>> medicine kits containing Doxycycline and Ivermectin.
>>
>> https://www.thedesertreview.com/opinion/columnists/indias-ivermectin-blackout---part-v-the-secret-revealed/article_9a37d9a8-1fb2-11ec-a94b-47343582647b.html
>>
>> It is illogical to blame mistreatment of a disease on the disease itself.
>>
>>
>> --
>> Lee
>>
>> ----[ http://gambaswiki.org/wiki/doc/netiquette ]----
>>
>
-------------- next part --------------
An HTML attachment was scrubbed...
URL: <http://lists.gambas-basic.org/pipermail/user/attachments/20211204/7090c24a/attachment.htm>