[Gambas-user] Reduced activity

[Jussi Lahtinen]

I will look later, if there is an explanation for the Indian numbers.
However, ivermectin and doxycycline do not explain it.

In vitro studies have shown that ivermectin works in principle, but in
practice the needed concentration is too neurotoxic. It is mostly a cheap
and desperate attempt, when nothing else is available. Thus it is not used
in western countries.

Here is quote from the review: "The blood levels of ivermectin at safe
therapeutic doses are in the 20–80 ng/ml range, while the activity against
SARS-CoV2 in cell culture is in the microgram range."

So, *you need a thousand times more ivermectin, than the safe limit.*
Full review here: https://www.nature.com/articles/s41429-020-0336-z]

There are some clinical trials still going on with ivermectin, but so far
the results are conflicting. Either "no help and just side-effects" or
"some very small help".
Also there are tons of studies with severe quality issues (again, more in
the Cochrane review).

I haven't look into the data, but some have suggested that ivermectin
generally works better in countries where the patients carry parasites. At
least that is logical, ivermectin is antiparasitic and parasites make us
weak.
Also it should be noted that there are already over thousand deaths due
self-medication with it. It should not be used until we know better, but it
doesn't look good.
For more details I recommend Cochrane review:
https://www.cochranelibrary.com/cdsr/doi/10.1002/14651858.CD015017.pub2/full

Also, note that ivermectin is in use in many countries without much success.

Doxycycline is an antibiotic, which blocks protein synthesis of a broad
spectrum of bacteria. So, in case of COVID induced co-infection it is used
in western countries.
It has also by some unknown mechanism some potential activity for some
viruses. But at least a trial done in the UK, showed it doesn't work
against COVID.
https://www.thelancet.com/journals/lanres/article/PIIS2213-2600(21)00310-6/fulltext
So, it seems the case is very similar to the ivermectin.

We do not eat them for a reason and it is not a conspiracy.


Jussi





On Sat, Dec 4, 2021 at 12:44 AM T Lee Davidson <t.lee.davidson at gmail.com>
wrote:

> On 12/3/21 1:50 PM, Christof Thalhofer wrote:
> > And is India (336) so good because there exists a natural immunity? Or
> are their numbers simply not right?
>
> Perhaps it is because the Indian government provided their people with
> medicine kits containing Doxycycline and Ivermectin.
>
> https://www.thedesertreview.com/opinion/columnists/indias-ivermectin-blackout---part-v-the-secret-revealed/article_9a37d9a8-1fb2-11ec-a94b-47343582647b.html
>
> It is illogical to blame mistreatment of a disease on the disease itself.
>
>
> --
> Lee
>
> ----[ http://gambaswiki.org/wiki/doc/netiquette ]----
>
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